Cell Counts & Dosage:Getting the Right Number
How many stem cells is enough? This isn’t just a technical question—it may be the difference between temporary relief and true regeneration.
Why Stem Cell Dosage Matters
A growing body of research now supports what we see in our clinic every day: more isn’t just more—it’s better when it comes to stem cell dosing. In many U.S.-based trials, injections using only 5–10 million cells have failed to show statistical benefit over cortisone injections.
“At one year post-injection, none of the three orthobiologic injections was superior to CSI control.”— Mautner et al., Nature Medicine, 2023
This study compared low-dose injections, but crucially, cell counts were too low—typically 5 to 10 million—and viability wasn’t emphasized. These design limitations, as Dr. Yi Song points out, may explain why the stem cell therapies underperformed.
Clinical Experience: 50 Million Cells Last Longer
In contrast, our clinic uses lab-expanded umbilical cord MSCs with verified 85–94% viability—a level rarely matched by frozen, non-manipulated cells used in many U.S. clinics. Patients who receive a single injection of 50 million cells into joints like the knee or shoulder often report significant pain reduction and improved mobility with results lasting 2–3 years or more.
A 2019 study in Stem Cell Research & Therapy evaluated injections of 10M, 20M, and 50M stem cells for knee osteoarthritis.
- Dose-dependent improvement in cartilage quality was observed, particularly in the 50 million cell group.
- No serious adverse effects were reported, and higher doses were well tolerated.
- MRI showed significantly better cartilage repair in the 50M group compared to 10M and 20M.
Effective stem cell therapy depends on two critical factors: the right dosage and high cell viability. We empower our patients with transparent, therapeutic doses of certified, high-viability cells to ensure your treatment is designed for results.
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